Association of Smoking Behavior, Intensity, and Time Since Cessation with Epigenetic Aging Biomarkers: Results from NHANES 1999-2002
Smoking was associated in a dose-dependent manner with accelerated epigenetic aging in former and current smokers. However, epigenetic age acceleration declines with time since smoking cessation among former smokers.
Authors
- Jamaji C. Nwanaji‐Enwerem (ORCID: https://orcid.org/0000-0003-0356-4867)
- Javier Pérez-García (ORCID: https://orcid.org/0000-0001-7813-4381)
- Nicole Gladish (ORCID: https://orcid.org/0000-0001-6039-7001)
- Mary B. Rice (ORCID: https://orcid.org/0000-0003-2538-391X)
- Belinda L. Needham (ORCID: https://orcid.org/0000-0001-5939-2027)
- Dennis Khodasevich (ORCID: https://orcid.org/0000-0003-1412-8251)
- Andrés Cárdenas (ORCID: https://orcid.org/0000-0003-2284-3298)
- Anne K. Bozack (ORCID: https://orcid.org/0000-0003-0046-5767)
- David H. Rehkopf (ORCID: https://orcid.org/0000-0002-7597-6513)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- University of Michigan (US)
- Stanford Health Care (US)
- Stanford Medicine (US)
- Center for Health Justice (US)
- Harvard Global Health Institute (US)
- New York University (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2025-12-19
- DOI
- https://doi.org/10.64898/2025.12.18.25342556
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences
- National Institute on Minority Health and Health Disparities