External Nasal Reconstruction in Patients With Extranodal Natural Killer (NK)/T-cell Lymphoma, Nasal Type

Extranodal NK/T-cell lymphoma, nasal type (ENKTL-NT), is a rare and aggressive lymphoma of NK or T-cell origin, characterized by necrotizing and destructive granulomatous lesions that primarily affect facial midline structures. In the head and neck region, it often leads to extensive destruction of soft tissue, bone, and cartilage, potentially resulting in external nasal deformity and necrosis. This study reports on nasal reconstruction and its clinical course in patients with ENKTL-NT. Two patients with ENKTL-NT, who achieved remission following chemoradiotherapy, underwent external nasal reconstruction. Both cases involved autologous tissue reconstruction. Although external nasal morphology improved in both cases, long-term follow-up revealed contracture and secondary deformity, suggesting that outcomes were not entirely satisfactory. Accurate assessment of the remaining nasal components-including soft tissue and skeletal framework-is critical for selecting an appropriate reconstructive strategy.

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Publication Details

Journal
Cureus
Published
2025-12-20
DOI
https://doi.org/10.7759/cureus.99730
Primary Topic
Nasal Surgery and Airway Studies
Type
article
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0.00
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article

External Nasal Reconstruction in Patients With Extranodal Natural Killer (NK)/T-cell Lymphoma, Nasal Type

Shunsuke Sakakibara, Tadashi Nomura, Misato Ueda
Cureus
Nasal Surgery and Airway Studies
article

External Nasal Reconstruction in Patients With Extranodal Natural Killer (NK)/T-cell Lymphoma, Nasal Type

Shunsuke Sakakibara, Tadashi Nomura, Misato Ueda
article en

Abstract

Extranodal NK/T-cell lymphoma, nasal type (ENKTL-NT), is a rare and aggressive lymphoma of NK or T-cell origin, characterized by necrotizing and destructive granulomatous lesions that primarily affect facial midline structures. In the head and neck region, it often leads to extensive destruction of soft tissue, bone, and cartilage, potentially resulting in external nasal deformity and necrosis. This study reports on nasal reconstruction and its clinical course in patients with ENKTL-NT. Two patients with ENKTL-NT, who achieved remission following chemoradiotherapy, underwent external nasal reconstruction. Both cases involved autologous tissue reconstruction. Although external nasal morphology improved in both cases, long-term follow-up revealed contracture and secondary deformity, suggesting that outcomes were not entirely satisfactory. Accurate assessment of the remaining nasal components-including soft tissue and skeletal framework-is critical for selecting an appropriate reconstructive strategy.

CureusVol. 17(12)
Hyogo Prefectural Cancer Center (JP), Kobe University (JP)
Openalex Percentile: Top 28%
Nasal Surgery and Airway Studies
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