Stable remission of depression after antidepressant treatment: prevalence and related sociodemographic and clinical characteristics in a longitudinal, real-world cohort
Nearly half of patients starting antidepressant medication reached stable remission. Higher depressive symptoms and higher dose - both likely reflecting more severe depression - were associated with lower remission rates. Findings highlight the need to identify and address factors hindering stable remission.
Authors
- Mariska Bot (ORCID: https://orcid.org/0000-0002-5488-1814)
- Sjoerd M. van Belkum (ORCID: https://orcid.org/0000-0002-2664-1717)
- Wilma Göttgens
- Suzanne A. Ligthart (ORCID: https://orcid.org/0000-0003-3216-1928)
- TOM K. BIRKENHÄGER
- Christiaan H. Vinkers (ORCID: https://orcid.org/0000-0003-3698-0744)
- Otto R Maarsingh (ORCID: https://orcid.org/0000-0002-3747-9217)
- Brenda W.J.H. Penninx (ORCID: https://orcid.org/0000-0001-7779-9672)
- Pierre M. Bet (ORCID: https://orcid.org/0000-0001-6735-7379)
- Jacqueline G. Hugtenburg
- Henricus G. Ruhé (ORCID: https://orcid.org/0000-0001-6072-0358)
- Ingrid A. Arnold
- Jan Spijker
- Huibert Burger
- Nina H. Grootendorst-van Mil
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Amsterdam Neuroscience (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Amsterdam University Medical Centers (NL)
- Pro Persona (NL)
- Vrije Universiteit Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.jad.2025.121011
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- ZonMw