RANKL enhances the expression of PEPT1/SLC15A1 and PEPT2/SLC15A2 in RAW264.7 cells
RANKL stimulation increased PEPT1/SLC15A1 and PEPT2/SLC15A2 levels in RAW264.7 cells, suggesting an increase in the intracellular uptake of MDP. This may promote osteoclast differentiation, potentially through NOD2activation or NOD2-independent mechanisms.
Authors
- Seiji Goda
- Aki Nishiura (ORCID: https://orcid.org/0000-0001-9295-2532)
- Nagako Sougawa
- Wakana Sugimoto
- Mana Shintani
- Hiroshi Inoue
Institutions
- Osaka Dental University (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.job.2025.100724
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00