The hidden link between cefiderocol resistance and increased virulence in Klebsiella pneumoniae: insights from a transposon-directed insertion-site sequencing-based investigation
These results emphasize the multifactorial nature of FDC resistance, involving both impaired drug entry and capsule-mediated protection, with potentially pleiotropic effects on bacterial virulence. Our study elucidates key genetic determinants of FDC resistance and highlights the complex interplay between antibiotic resistance and bacterial pathogenicity.
Authors
- Katharina Schaufler (ORCID: https://orcid.org/0000-0002-2669-8799)
- Luca Guardabassi (ORCID: https://orcid.org/0000-0002-2389-5084)
- Dennis Nurjadi (ORCID: https://orcid.org/0000-0002-1278-5939)
- Yibing Ma (ORCID: https://orcid.org/0009-0002-0143-7477)
- Elias Eger (ORCID: https://orcid.org/0000-0002-5514-8083)
- Justus U. Müller (ORCID: https://orcid.org/0009-0000-0546-7273)
- Bimal Jana (ORCID: https://orcid.org/0000-0002-4634-8470)
- Michael Schwabe (ORCID: https://orcid.org/0009-0006-8098-9841)
- Mattia Pirolo
Institutions
- University of Copenhagen (DK)
- Universitätsmedizin Greifswald (DE)
- Massachusetts General Hospital (US)
- University Hospital Schleswig-Holstein (DE)
- Helmholtz Centre for Infection Research (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Clinical Microbiology and Infection
- Published
- 2025-12-20
- DOI
- https://doi.org/10.1016/j.cmi.2025.12.010
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59