Static Visual Agnosia Following Awake Resection of a Left Frontal Low-Grade Glioma: A Case Report of Ventral Stream Network Disruption (“Astatopsia”)

<b>Background and Clinical Significance</b>: Visual agnosia and speech production deficits are well-described sequelae of neurosurgical interventions, but their selective dissociation remains rare. This report presents an unusual combination of postoperative deficits following awake resection of a left frontal low-grade glioma. <b>Case Presentation</b>: We present the case of a right-handed female with left hemisphere language dominance who had a left frontal low-grade glioma. Preoperatively, she exhibited anomia and dysexecutive syndrome, including difficulty completing everyday goal-directed tasks such as sending emails and paying for parking. Following awake tumor resection, she developed two rare, dissociated deficits: (1) speech restricted to infinitive verb forms and (2) selective visual agnosia for static images, with preserved recognition of dynamic stimuli. <b>Conclusions</b>: This uncommon clinical constellation highlights the vulnerability of left frontal language and ventral visual processing networks during surgery and supports the dual-stream model of vision and language production. We describe a selective form of static visual agnosia affecting static images with relative preservation of dynamic and object recognition, for which we use the descriptive label "astatopsia". This peculiar clinical condition is rarely documented in this particular combination and has not, to the best of our knowledge, previously been denominated in such a manner in the literature.

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Publication Details

Journal
Reports — Medical Cases Images and Videos
Published
2025-12-19
DOI
https://doi.org/10.3390/reports9010001
Primary Topic
Spatial Neglect and Hemispheric Dysfunction
Type
article
Field-Weighted Citation Impact
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article

Static Visual Agnosia Following Awake Resection of a Left Frontal Low-Grade Glioma: A Case Report of Ventral Stream Network Disruption (“Astatopsia”)

Reports — Medical Cases Images and Videos
Spatial Neglect and Hemispheric Dysfunction
article

Static Visual Agnosia Following Awake Resection of a Left Frontal Low-Grade Glioma: A Case Report of Ventral Stream Network Disruption (“Astatopsia”)

article en

Abstract

<b>Background and Clinical Significance</b>: Visual agnosia and speech production deficits are well-described sequelae of neurosurgical interventions, but their selective dissociation remains rare. This report presents an unusual combination of postoperative deficits following awake resection of a left frontal low-grade glioma. <b>Case Presentation</b>: We present the case of a right-handed female with left hemisphere language dominance who had a left frontal low-grade glioma. Preoperatively, she exhibited anomia and dysexecutive syndrome, including difficulty completing everyday goal-directed tasks such as sending emails and paying for parking. Following awake tumor resection, she developed two rare, dissociated deficits: (1) speech restricted to infinitive verb forms and (2) selective visual agnosia for static images, with preserved recognition of dynamic stimuli. <b>Conclusions</b>: This uncommon clinical constellation highlights the vulnerability of left frontal language and ventral visual processing networks during surgery and supports the dual-stream model of vision and language production. We describe a selective form of static visual agnosia affecting static images with relative preservation of dynamic and object recognition, for which we use the descriptive label "astatopsia". This peculiar clinical condition is rarely documented in this particular combination and has not, to the best of our knowledge, previously been denominated in such a manner in the literature.

Reports — Medical Cases Images and VideosVol. 9(1)
Marche Polytechnic University (IT), Azienda Ospedaliero Universitaria Ospedali Riuniti (IT), Ospedale Policlinico San Martino (IT), Azienda Ospedaliera Universitaria Pisana (IT), University of Genoa (IT)
Gender equality, Quality Education
Openalex Percentile: Top 34%
Spatial Neglect and Hemispheric Dysfunction
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