Navigating obesity through nutrigenetic dietary interventions: Evidence from young Saudi women

Nutrigenetic dietary interventions offer personalised strategies for weight management, yet evidence from Middle Eastern populations—particularly young Saudi women—remains limited. This study examined the effect of a three-month nutrigenetic intervention on body weight and adiponectin levels. Thirty-one Saudi women aged 18–24 years with overweight or obesity completed a personalised nutrigenetic intervention informed by variants in six genes ( FTO, MC4R, CLOCK, PPARG, LPL, TCF7L2 ). Anthropometric and biochemical markers were measured at baseline and post-intervention. Weight and adiponectin changes were analysed using Wilcoxon signed-rank tests; genotype-group differences were assessed using Kruskal–Wallis tests. Weight significantly decreased (median change: −1.3 kg; p = 0.008). Adiponectin concentrations increased significantly (median change: +1.74 μg/mL; p < 0.001). No significant genotype-specific differences were observed for weight or adiponectin outcomes (all p > 0.05). This nutrigenetic dietary intervention produced clinically meaningful improvements in weight and metabolic biomarkers independent of genotype. Findings support the feasibility of integrating personalised nutrition into obesity-management strategies for young Saudi women.