Heat stress-induced heat shock protein 90 alpha family class A member 1 upregulation stabilizes yes-associated protein through ubiquitination inhibition to boost hepatic cancer radiofrequency hyperthermia resistance

This study revealed that heat stress upregulates HSP90AA1, which stabilizes YAP by inhibiting ubiquitination, activates the YAP pathway, and protects liver cancer cells from cytotoxicity. These findings suggest that HSP90AA1 may be a potential therapeutic target for HCC.

Institutions

Publication Details

Journal
Cell Stress and Chaperones
Published
2025-12-19
DOI
https://doi.org/10.1016/j.cstres.2025.100140
Primary Topic
Heat shock proteins research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Heat stress-induced heat shock protein 90 alpha family class A member 1 upregulation stabilizes yes-associated protein through ubiquitination inhibition to boost hepatic cancer radiofrequency hyperthermia resistance

Cell Stress and Chaperones
Heat shock proteins research
article

Heat stress-induced heat shock protein 90 alpha family class A member 1 upregulation stabilizes yes-associated protein through ubiquitination inhibition to boost hepatic cancer radiofrequency hyperthermia resistance

article en

Abstract

This study revealed that heat stress upregulates HSP90AA1, which stabilizes YAP by inhibiting ubiquitination, activates the YAP pathway, and protects liver cancer cells from cytotoxicity. These findings suggest that HSP90AA1 may be a potential therapeutic target for HCC.

Cell Stress and ChaperonesVol. 31(1)
Zhejiang Cancer Hospital (CN)
Good health and well-being
Openalex Percentile: Top 37%
Heat shock proteins research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Heat stress-induced heat shock protein 90 alpha family class A member 1 upregulation stabilizes yes-associated protein through ubiquitination inhibition to boost hepatic cancer radiofrequency hyperthermia resistance · Cell Stress and Chaperones (2025) | TGRS Research Map | TGRS