metabolomics-HD-analysis

This repository contains the analysis code, data tables, and supplementary material for a plasma metabolomics study in Huntington’s disease. Contents scripts/R scripts used for statistical analyses data/A table with metabolomic data for all individuals (Excel files) supplementary/Supplementary Methods and Results (Word document) Description The project investigates plasma lipidomic signatures associated with: the transition from premanifest to early manifest Huntington’s disease motor symptom severity in early manifest individuals Analyses include: logistic regression with Monte Carlo cross-validation metabolite correlation network analysis (WGCNA) partial least squares regression (PLSR) Software Analyses were performed in R using: glmnet ROCR WGCNA mixOmics Notes This repository is provided for transparency and reproducibility. Raw data sharing is subject to ethical and regulatory restrictions.