Ischemic vs. Nonischemic Cardiomyopathy in TAVR for Moderate Aortic Stenosis: A TAVR UNLOAD Sub Analysis
•This exploratory analysis of the Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure trial did not identify evidence of a differential treatment effect of transcatheter aortic valve replacement compared to clinical aortic stenosis surveillance according to cardiomyopathy etiology (ischemic versus nonischemic) in patients with heart failure with reduced ejection fraction and moderate aortic stenosis.•The study was underpowered to definitively exclude a potential modifying effect of cardiomyopathy etiology, and any differential treatment response may require longer follow-up to become apparent.
Institutions
- NewYork–Presbyterian Hospital (US)
- University of California, San Francisco (US)
- University of Cologne (DE)
- Cornell University (US)
- Leiden University Medical Center (NL)
- New York Hospital Queens (US)
- Sahlgrenska University Hospital (SE)
- Erasmus MC (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Ford (Germany) (DE)
- St. Francis Hospital (US)
- Cardiovascular Research Foundation (US)
- University Hospital Cologne (DE)
- Cardialysis (Netherlands) (NL)
- Université Laval (CA)
- Weill Cornell Medicine (US)
- University of San Francisco (US)
- Columbia University (US)
- University of Gothenburg (SE)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Structural Heart
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.shj.2025.100787
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Edwards Lifesciences