Anti-inflammatory constituents from Murraya paniculata var. omphalocarpa

One undescribed coumarin, (2′ S )-isomurralonginol 1′- O -(2′′ R )-methylbutyrate ( 1 ), together with thirteen known coumarins, were isolated successively from the dried leaves of Murraya paniculata var. omphalocarpa Hayata (Rutaceae). In addition, two alkaloids, two coumarin-naphthoquinones, three coumarins, and one alkyl phenylpropanoate were also identified from the stem bark of the same plant. The undescribed coumarin 1 was characterized by the spectroscopic and spectrometric analytical methods, and the known compounds were identified by comparison of their physical and spectral data with those reported. Some isolated compounds were examined for their inhibitory effects on superoxide anion generation and elastase release. The results indicated that some isolates 4 , 6 , 16 , and 18 exhibited significant anti-inflammatory potential, with IC 50 values for the inhibition of superoxide anion generation ranging from 0.002 to 5.1 µg/mL. • One undescribed and thirteen known coumarins were isolated from the titled plant. • Osthole ( 4 ) exhibited significant inhibition of superoxide anion generation. • Docking indicated the bioactivities resulted from multiple mechanisms.