HDAC4 Promotes Neuroprotection of Retinal Ganglion Cells After Optic Nerve Injury

Enhancement of HDAC4 activity promotes RGC survival and axon regeneration in a model of RGC injury, normalizing RGC gene expression toward the uninjured state. HDAC4 is thereby identified as a novel target in the development of therapeutics for RGC protection and restoration of visual function.

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Publication Details

Journal
Investigative Ophthalmology & Visual Science
Published
2025-12-19
DOI
https://doi.org/10.1167/iovs.66.15.60
Primary Topic
Histone Deacetylase Inhibitors Research
Type
article
Field-Weighted Citation Impact
0.00

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article

HDAC4 Promotes Neuroprotection of Retinal Ganglion Cells After Optic Nerve Injury

Investigative Ophthalmology & Visual Science
Histone Deacetylase Inhibitors Research
article

HDAC4 Promotes Neuroprotection of Retinal Ganglion Cells After Optic Nerve Injury

article en

Abstract

Enhancement of HDAC4 activity promotes RGC survival and axon regeneration in a model of RGC injury, normalizing RGC gene expression toward the uninjured state. HDAC4 is thereby identified as a novel target in the development of therapeutics for RGC protection and restoration of visual function.

Investigative Ophthalmology & Visual ScienceVol. 66(15)
Vision Eye Institute (AU), Stanford Medicine (US)
Research to Prevent Blindness, National Institutes of Health
Life in Land
Openalex Percentile: Top 37%
Histone Deacetylase Inhibitors Research
DOIOpen Access PDFOpenAlex
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HDAC4 Promotes Neuroprotection of Retinal Ganglion Cells After Optic Nerve Injury · Investigative Ophthalmology & Visual Science (2025) | TGRS Research Map | TGRS