Transcriptomic and neurotransmitter correlates of structure and function spatial variations patterns in spinocerebellar Ataxia
Our convergent imaging-transcriptomic analysis integrates direct molecular vulnerability and CTC-based transsynaptic degeneration, yielding a unified systems-level view of SCA. These findings go beyond correlation by prioritizing molecular pathways and non-neuronal cellular targets and enabling network-informed prediction of additional vulnerable regions.
Institutions
- Fujian Medical University (CN)
- Beijing Normal University (CN)
- China-Japan Friendship Hospital (CN)
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Tongji Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.nbd.2025.107228
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00