Evaluation of Effectiveness of Ornidazole (Ornigreat GelTm), Metronidazole (Metrohex PlusTm), Silver Nanoparticle Gel (Megaheal GelTm) And Oxygen Releasing Formula (Blue M GelTm) Gel as an Adjunct to Phase I Therapy in The Management of Stage I Grade

Abstract Background: Periodontitis is an inflammatory disease induced by complex interactions between the host immune system and pathogens that affect the integrity of teeth supporting tissues. The primary goal of periodontal treatment is the elimination or reduction in the number of pathogenic bacteria. Local drug delivery agents have been used as an adjunct to SRP has been successfully used as non-surgical treatment and helps to eradicate the pathogenic bacteria which are present into the deeper structure of periodontium. The purpose of the study is to evaluate the clinical and microbiological efficacy of subgingival application of ornidazole, metronidazole, silver nano particle gel and blue M gel used as an adjunct to Phase I therapy in the treatment of Stage I Grade A/B periodontitis. Material and Methods: Following non-surgical therapy, a total of 140 patients diagnosed with Stage I Grade A/B periodontitis having minimum of 5 teeth with PPD between 5-6 mm were randomly selected. Treatment consisted of subgingival application of ornidazole, metronidazole, silver nano particle gel and blue M gel as an adjunct to SRP in group 1/site1, group 2/site 2, group 3/site 3 and group 4/Site 4 respectively. Baseline and follow up measurements included PI, GI, PPD, CAL and evaluation of the total microbial load (Colony Forming Units/ml). Results: On clinical measurement, all the four groups (ornidazole, metronidazole, silver nano particle gel and blue M gel) showed significant improvement in PI, GI, PPD and CAL gain from baseline to 3 months of time interval. On microbiological analysis, group 4/site 4 and group 3/sites 3 showed a significant reduction in total microbial load from 20.09×102±14.75 to 4.30×102±6.11 and 21.72×102±18.13 to 3.67×102±4.72 respectively from baseline to 3 months of intervention. On intragroup comparison the p˂0.001 found to be statistically significant for all the four groups/sites with less concentration of anaerobic microflora in comparison with aerobic microflora. Conclusion: Local drug delivery agent (ornidazole, metronidazole, silver nano particle gel and blue M gel) as additional therapy with SRP manifested promising outcome along with substantial improvement as clinical and microbiological parameter.