Investigating the causal roles of cholesterol and triglyceride subfractions across lipoproteins in irritable bowel syndrome: a Mendelian randomization study

Whereas triglycerides conveyed a uniformly adverse effect on IBS risk regardless of lipoprotein carrier, cholesterol displayed a net protective signal across most particle classes. This dichotomy implies that lipid-centred interventions should discriminate between the two moieties: dietary or pharmacological strategies that selectively lower triglycerides while preserving-or even augmenting-cholesterol in specific lipoprotein fractions may offer a rational, mechanistically grounded approach to IBS prevention and management.