Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study
Lower lGI, which is associated with impaired signaling efficiency, was observed in the PTSD group compared with the control group for the ventromedial prefrontal cortex, a region that has been strongly implicated in associative fear learning and extinction. It is possible that PTSD accelerates the typical age-associated decline in lGI of the rostral middle frontal cortices.
Institutions
- Université de Tours (FR)
- Northwestern University (US)
- University of Southern California (US)
- Leiden University (NL)
- Texas A&M Health Science Center (US)
- Western University (CA)
- University of Minnesota (US)
- Nebraska Medical Center (US)
- Pennsylvania State University (US)
- Central European Institute of Technology (CZ)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of Arizona (US)
- Radboud University Nijmegen (NL)
- Emory University (US)
- Inserm (FR)
- Baylor University (US)
- The University of Texas at Dallas (US)
- Tel Aviv University (IL)
- University of Groningen (NL)
- Duke University (US)
- Palo Alto University (US)
- Baylor College of Medicine (US)
- Wayne State University (US)
- The University of Texas at Arlington (US)
- Utrecht University (NL)
- Chinese Academy of Sciences (CN)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- VA Palo Alto Health Care System (US)
- Masaryk University (CZ)
- Heidelberg University (DE)
- University of Münster (DE)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Leiden University Medical Center (NL)
- McLean Hospital (US)
- Ghent University Hospital (BE)
- University Hospital Heidelberg (DE)
- University of Rochester Medical Center (US)
- UNSW Sydney (AU)
- Yale University (US)
- New York Psychoanalytic Society and Institute (US)
- Arq Psychotrauma Expert Group (NL)
- Centre Hospitalier Universitaire de Tours (FR)
- Clinical Investigation Center Plurithematic Tours (FR)
- Central Institute of Mental Health (DE)
- Texas A&M Health Science Center (US)
- Amsterdam Neuroscience (NL)
- Minneapolis VA Health Care System (US)
- Institute of Psychology, Chinese Academy of Sciences (CN)
- Stanford Medicine (US)
- Academic College of Tel Aviv-Yafo (IL)
- Wisconsin Division of Public Health (US)
- De Viersprong (NL)
- Center for Occupational Research and Development (US)
- University of Chinese Academy of Sciences (CN)
- New York State Psychiatric Institute
- University of Nebraska Medical Center (US)
- Charité - Universitätsmedizin Berlin (DE)
- Nanjing Medical University (CN)
- Neuroscience Research Australia (AU)
- The University of Texas at Austin (US)
- Vrije Universiteit Amsterdam (NL)
- Nanjing University (CN)
- Texas A&M University (US)
- University of Haifa (IL)
- Bryan College (US)
- Stanford University (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100679
- Primary Topic
- Memory and Neural Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Michael J. Fox Foundation for Parkinson's Research
- National Alliance for Research on Schizophrenia and Depression
- National Natural Science Foundation of China
- ZonMw
- Chinese Academy of Sciences
- National Institutes of Health
- National Social Science Fund of China
- Institute of Psychology, Chinese Academy of Sciences
- National Institute of Mental Health
- National Institute of Child Health and Human Development
- National Center for Research Resources
- NIH Clinical Center
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development