Network-wide morphometric organization deficits and transcriptomic correlates in Parkinson's disease with freezing of gait: A morphometric inverse divergence study

FOG is characterized by widespread reductions in morphometric network organization that co-vary with spatially patterned cortical gene expression. These multi-scale findings link macroscale network vulnerability to molecular context and nominate testable targets for mechanism-informed and therapeutic studies in PD-related gait freezing.

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Publication Details

Journal
Neurobiology of Disease
Published
2025-12-19
DOI
https://doi.org/10.1016/j.nbd.2025.107230
Primary Topic
Neurological disorders and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Network-wide morphometric organization deficits and transcriptomic correlates in Parkinson's disease with freezing of gait: A morphometric inverse divergence study

Neurobiology of Disease
Neurological disorders and treatments
article

Network-wide morphometric organization deficits and transcriptomic correlates in Parkinson's disease with freezing of gait: A morphometric inverse divergence study

article en

Abstract

FOG is characterized by widespread reductions in morphometric network organization that co-vary with spatially patterned cortical gene expression. These multi-scale findings link macroscale network vulnerability to molecular context and nominate testable targets for mechanism-informed and therapeutic studies in PD-related gait freezing.

Neurobiology of DiseaseVol. 218
Guangzhou First People's Hospital (CN), South China University of Technology (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 32%
Neurological disorders and treatments
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