Adlercreutzia-modulated polyunsaturated fatty acid metabolism underlies nicotine’s anti-obesity effects

Collectively, our study elucidates the critical involvement of gut microbiota in nicotine-induced obesity amelioration, uncovers a novel <i>Adlercreutzia</i>-PUFA metabolic axis mediating nicotine's anti-obesity effects, and highlight <i>Adlercreutzia</i> potentiation as a promising microbiota-directed invention strategy for obesity and metabolic syndrome.