Post-translational modification gene signatures implicate FBXW7 in immune and vascular dysregulation of Moyamoya disease
Our study identifies PTM-related genes involving the development of MMD. Especially, we found that FBXW7 and HLA-A bridging immune dysregulation and vascular dysfunction. Our work provide innovative insights into mechanisms of MMD pathogenesis and candidate therapeutic targets for precision therapy of MMD.
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fgene.2025.1723233
- Primary Topic
- Moyamoya disease diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China