Beyond linearity: a threshold effect links serum creatinine to SIRI in osteoporotic fractures

Among hospitalized patients with OPF, higher serum creatinine is associated with higher SIRI, with a clinically relevant threshold at 78 μmol/L. For creatinine values above this threshold, each 1 μmol/L increment corresponds to a 0.033 increase in SIRI. These findings support routine monitoring of creatinine, inflammatory status, and renal function in this population and warrant confirmation in prospective studies.