The GDF5 rs143384 Polymorphism Is Associated with the Severity of Knee Osteoarthritis and Shorter Stature in Female Brazilian Patients: A Cross-Sectional Study
The <i>GDF5</i> rs143384 polymorphism was associated with greater KOA severity and shorter stature in female patients. These results suggest that this variant may contribute to phenotypic variability in patients with knee osteoarthritis, helping to refine clinical characterization and stratification in this population, contributing to personalized diagnoses and guiding future changes in treatment guidelines for knee osteoarthritis.
Institutions
- Universidade Federal Fluminense (BR)
- Instituto Federal Fluminense (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Instituto Nacional de Traumatologia e Ortopedia (BR)
Publication Details
- Journal
- Genes
- Published
- 2025-12-18
- DOI
- https://doi.org/10.3390/genes16121520
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Universidade do Estado do Rio de Janeiro