Systematic screening of tryptophan metabolism identifies site- and microbial-specific signatures of tryptophan utilization in experimental colitis
Our findings demonstrate that mucosal NAD⁺ <i>de novo</i> synthesis is a microbially regulated metabolic process that alleviates intestinal inflammation and may represent a novel therapeutic target in IBD through modulation of the gut microbiota or their metabolites.
Institutions
- Pennsylvania State University (US)
- Government of Nova Scotia (CA)
- Unité de Nutrition Humaine (FR)
- University Hospital Schleswig-Holstein (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-18
- DOI
- https://doi.org/10.64898/2025.12.16.693850
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Joachim Herz Stiftung
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Else Kröner-Fresenius-Stiftung
- National Institutes of Health
- Huck Institutes of the Life Sciences