Selective Activation of Na <sub>V</sub> 1.3 Restores Lymphatic Contractility in Age and Injury
Na <sub>V</sub> 1.3 is a selectively druggable ion channel in adult lymphatic muscle that can be recruited to restore lymphatic pump function across aging and injury. Targeted Na <sub>V</sub> 1.3 activation provides a molecular entry point for treating diseases characterized by lymphatic pump failure, a domain with no existing pharmacologic therapies.
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Bucknell University (US)
- John Brown University (US)
- Hadassah Medical Center (IL)
- Massachusetts General Hospital (US)
- Universidad del Noreste (MX)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-17
- DOI
- https://doi.org/10.64898/2025.12.15.694435
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00