A warming-yang herbal decoction protects against high-altitude hypoxia–induced osteoblast injury through modulation of HIF-1 signaling

The findings implicated HIF-1 signaling dysregulation in inducing high-altitude hypoxia-induced osteoblast injury and osteoporosis. GAWD may reduce hypoxia-induced cellular stress through recovering redox homeostasis and adjusting HIF-1/VEGF signaling. Collectively, this, study offers early molecular evidence supporting the utility of GAWD as a traditional Chinese medicine-based intervention for the prevention of bone metabolic disorders due to chronic hypoxic exposure.