ADAM17 and related epithelial injury markers in bronchoalveolar lavage and blood distinguish COPD from controls

Our findings highlight an overabundance of ADAM17 and pADAM17 in COPD airways that is accentuated beyond smoking-induced changes. This broad catalytic-complex analysis has both combined individual biomarkers and discovered more novel disease-specific biomarkers that may all relate to the overarching functionality of ADAM17 in COPD, warranting further investigation into the role this enzyme plays in COPD pathogenesis.

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Publication Details

Journal
Respiratory Medicine
Published
2025-12-18
DOI
https://doi.org/10.1016/j.rmed.2025.108596
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
Field-Weighted Citation Impact
0.00

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article

ADAM17 and related epithelial injury markers in bronchoalveolar lavage and blood distinguish COPD from controls

Respiratory Medicine
Chronic Obstructive Pulmonary Disease (COPD) Research
article

ADAM17 and related epithelial injury markers in bronchoalveolar lavage and blood distinguish COPD from controls

article en

Abstract

Our findings highlight an overabundance of ADAM17 and pADAM17 in COPD airways that is accentuated beyond smoking-induced changes. This broad catalytic-complex analysis has both combined individual biomarkers and discovered more novel disease-specific biomarkers that may all relate to the overarching functionality of ADAM17 in COPD, warranting further investigation into the role this enzyme plays in COPD pathogenesis.

Respiratory MedicineVol. 251
Lund University (SE)
Skånes universitetssjukhus, Interreg
Good health and well-being
Openalex Percentile: Top 29%
Chronic Obstructive Pulmonary Disease (COPD) Research
DOIOpen Access PDFOpenAlex
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ADAM17 and related epithelial injury markers in bronchoalveolar lavage and blood distinguish COPD from controls · Respiratory Medicine (2025) | TGRS Research Map | TGRS