A Sesquiterpene Lactone with Anti-Inflammatory Activity Modulates the Crosstalk between NF-kB and AHR Pathways

Funding Information: This work was supported by EU Horizon 2020 Research & Innovation programme (H2020-NMBP-BIO-2017) (grant number 760891), European Commission program Teaming for Excellence, Grant No. 101060346, the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement No. 951921, NORTE2030-FEDER-01777300 - SCALE-ImmunoHUB2030 supported by Norte Portugal Regional Operational Programme (NORTE 2030), under the PORTUGAL 2030 Partnership Agreement, through the European Regional Development Fund (FEDER); Ludwig Institute for Cancer Research Core Award; COMPETE2030-FEDER-00693400, supported by FEDER and national Funds (Fundac\u0327a\u0303o para a Cie\u0302ncia e Tecnologia, FCT), operation number 15824 relative to applications to MPr-2023-12. iNOVA4Health (LISBOA-01-0145-FEDER-007344; UIDB/04462/2020), cofunded by FCT/Ministe\u0301rio da Cie\u0302ncia e do Ensino Superior (MCTES) through national funds and by FEDER under the PT2020 Partnership Agreement, and also LS4FUTURE Associated Laboratory (LA/P/0087/2020) are acknowledged. C.J.G.P. (grant No. 2022.11465.BD), C.R.P. (grant No. 2023.00453.BD), and I.P.S. (grant No. 2023.02417.BD) are recipients of PhD fellowships from FCT. P.M.-A., A.T.J., R.S., Y.L., and P.L. acknowledge support from the Ludwig Institute for Cancer Research Core Award. P.M.-A. and S.M. thank funding from the European Union\u2019s Horizon 2020 research and innovation programme under grant agreement No. 951921, NORTE2030-FEDER-01777300 - SCALE-ImmunoHUB2030, and COMPETE2030-FEDER-00693400. C.N.S acknowledges European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation program under grant agreement No 804229. Publisher Copyright: © 2025 American Chemical Society