TNFα protein, DNA methylation, mRNA and miRNA expression evaluation in multiple sclerosis
The data indicate that TNFα upregulation in RRMS is associated with promoter hypomethylation and reduced miR-130a-3p expression, suggesting a coordinated epigenetic and post-transcriptional control of this cytokine. The parallel trends observed in saliva and serum highlight the potential use of salivary TNFα and miR-130a-3p as minimally invasive biomarkers for MS monitoring and early diagnosis.
Institutions
- National Institutes of Health (US)
- Universidade do Porto (PT)
- University of Chieti-Pescara (IT)
- National Institute on Aging (US)
- Institute of Biomedical Science (GB)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-12-17
- DOI
- https://doi.org/10.3389/fmolb.2025.1730177
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health