Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

In patients consuming clozapine after alcohol intake, dynamic monitoring of CK and myoglobin should be implemented regardless of whether toxicology results are within normal limits. Early implementation of blood purification can effectively disrupt the rhabdomyolysis-renal injury cascade, thereby securing a critical therapeutic window for clinical intervention.

Institutions

Publication Details

Journal
Frontiers in Toxicology
Published
2025-12-17
DOI
https://doi.org/10.3389/ftox.2025.1692362
Primary Topic
Muscle and Compartmental Disorders
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

Frontiers in Toxicology
Muscle and Compartmental Disorders
article

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

article en

Abstract

In patients consuming clozapine after alcohol intake, dynamic monitoring of CK and myoglobin should be implemented regardless of whether toxicology results are within normal limits. Early implementation of blood purification can effectively disrupt the rhabdomyolysis-renal injury cascade, thereby securing a critical therapeutic window for clinical intervention.

Frontiers in ToxicologyVol. 7
Fudan University (CN), Huashan Hospital (CN)
Good health and well-being
Openalex Percentile: Top 28%
Muscle and Compartmental Disorders
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review · Frontiers in Toxicology (2025) | TGRS Research Map | TGRS