Tumor intrinsic properties dictate Fc receptor expression and cancer cachexia associated increase in checkpoint inhibitor clearance

These findings provide the first evidence that FcRs, critical for the efficacy and pharmacokinetics of many ICI and other IgG mAbs, are altered in a tumor-dependent manner. Furthermore, in the absence of a tumor, cachexia phenotype may not coincide with inflammation in the form of altered immune cell populations and elevated catabolic clearance of IgG mAbs, suggesting these features arise from properties intrinsic to the tumor.