Efficacy of hyaluronic acid on the inhibition of periodontal bridging organisms Fusobacterium nucleatum and Prevotella intermedia: An in vitro study

High-molecular-weight HA shows potential as a nonantibiotic support agent in periodontal therapy by selectively inhibiting key anaerobic bacteria involved in biofilm development. Its two actions, antimicrobial and immunomodulatory, highlight its importance by breaking down pathogenic cooperation and supporting periodontal healing. Further research with multispecies biofilms, clinical isolates, and host interaction models is necessary for clinical application.