A case of delayed-onset postoperative pyoderma gangrenosum complicated with chronic myelomonocytic leukemia treated with systemic corticosteroids and spesolimab

Pyoderma gangrenosum (PG) constitutes an uncommon form of neutrophilic dermatosis frequently linked to systemic diseases, notably hematologic malignancies. Chronic myelomonocytic leukemia (CMML) provides a distinctive framework for the pathogenesis of PG, attributable to the mutual dysregulation of myeloid cell function. This case report documenting the delayed emergence of PG in conjunction with CMML postsurgery underscores the pivotal role of inhibiting the interleukin 36 (IL-36) pathway in managing PG associated with CMML.