Cardiac Phenotypes and Endophenotypes in Schizophrenia : A systematic Review

Among all cardiac anomalies reported in schizophrenia, autonomic dysfunction, particularly HRV impairment, was the only one that fulfilled the endophenotype criteria. However, most of the reviewed studies were observational, which limits the robustness of our conclusions. Future heritability and multi-omic studies are needed to understand the complex pathogenomic interlink between mental and heart diseases.