The effect of eight weeks of combined exercise on interleukin-6, C-reactive protein, and lipid profile in patients with coronary artery disease.

Background: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, claiming approximately 17.9 million lives annually. Given the role of physical activity in the prevention and management of cardiovascular diseases, investigating the impact of exercise on inflammatory markers is of particular importance. Therefore, this study was conducted to evaluate the effect of eight weeks of combined exercise on interleukin-6, C-reactive protein, and lipid profile in individuals with coronary artery disease. Method :In a randomized clinical trial, 24 patients with coronary artery disease, overweight or obesity, and an average age of 59 ± 8 years with a body mass index of 27.76 ± 0.42 were randomly assigned to two groups: combined exercise training and control. The training group followed a specific exercise protocol for eight weeks, with three sessions per week. Venous blood samples were collected before and after the intervention. For data analysis, the Shapiro-Wilk test was used to assess normality, while analysis of covariance and Bonferroni post hoc test were applied to compare mean values between groups. The final analysis was conducted using SPSS version 22. Results : The results showed that combine exercises led to a significant decrease in the levels of inflammatory response protein (CRP) (p=0.025) and IL-6 (p=0.011) compared to the control group. Also, despite the decrease in the mean TG, TC, LDL indices and the increase in HDL, the changes were not significant (P>.05). Conclusion : The results show that 8 weeks of combine training can reduce inflammatory markers and reduce the risk of cardiovascular disease.