From the lab to the bench: scaling up regulatory T cell therapy

Regulatory T cells offer advantages for immune modulation in cell therapies due to their multiple mechanisms of action, including regulation of antigen-presenting cells and T cell effector function. This article addresses the key challenges in the evolving field of Treg-based therapy, emphasizing safety, accessibility, and manufacturing efficiency, and explores strategies such as the implementation of automation and closed systems to enhance operational consistency and minimize contamination risks. The Gibco™ Dynabeads™ Treg Xpander System are showcased for their ability to effectively expand Tregs. Additionally, the Gibco™ Cell Therapy Systems™ portfolio is highlighted for its rigorous safety testing and GMP compliance.