A comparative evaluation of biomimetic remineralization potential of enamel white spot lesions: A Pilot in-vitro study

Abstract Introduction: The remineralization potential of three recent remineralizing agents on white spot lesions were compared and evaluated using the Vicker’s microhardness testing machine. This short study aims to evaluate and compare the remineralization potential of recently introduced remineralizing agents like Curodont Protect Gel, GC Tooth Mousse Plus, Dente 91 on surface hardness of white spot lesions in human teeth1. Method: Thirty single rooted human premolars extracted due to periodontal reasons or orthodontic reasons were chosen for this study. The teeth were decoronated at Cemento-enamel junction level. Samples were then mounted in auto-polymerization acrylic resin. All the groups were subjected to demineralization process to induce white spot lesions. A post demineralization vicker hardness test was performed followed by random allocation to the three groups. The three groups were namely Self-assembling peptide (P11-4), Casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and Nano-hydroxyapatite. A post remineralization Vickers hardness test was conducted to evaluate the remineralization potential of tested agents. Result: An analysis of variance (ANOVA) was performed to determine the significant difference of Vickers microhardness. Self-assembling peptide showed the highest microhardness value. Conclusion: Self-assembling peptide (Curodont Protect Gel) was more efficient than nanohydroxyapatite(Dente-91) and CPP-ACP (GC Tooth Mousse Plus) for the prevention of white spot lesions(WSLs).