Evaluating the Efficacy of Placental Extract Gel (Placentrex®) and High Concentration Oxygen Oral Gel (Blue®M) TM as an Adjunct to Scaling and Root Planing in Stage II Periodontitis Patients: A Randomized Controlled Clinical Trial

Abstract Introduction: Periodontitis is a chronic disease-causing tissue damage and tooth loss; while antibiotics help reduce the pathogens, new adjunctive treatments are emerging. Human placental extracts, rich in NADPH, promote nitric oxide-mediated healing and may improve outcomes after non-surgical periodontal therapy. Additionally, oxygen supports healing by enhancing cellular metabolism, bacterial clearance, and tissue regeneration; slow-release formulations like Blue®M gel target anaerobic bacteria in periodontal pockets. Therefore, this study investigated the clinical efficacy of placental extract gel (Placentrex®), high concentration oxygen oral gel (Blue®M) TM as an adjunct to scaling and root planning in stage II periodontitis patients. Method: Study subjects with stage II periodontitis having at least two non-adjacent teeth with probing pocket depth of 3 to 4mm, who met the inclusion criteria were enrolled for the study. The sample size of 8 patients per group was taken. The total sample size was 24 for two groups. Group A: 20 sites received SRP + Placentrex® Group B: 20 sites will receive SRP + Blue®M Group C: 20 sites will receive SRP. Clinical parameters evaluated at 4 weeks & 8-week intervals where, Gingival Index (GI), Modified Papillary Bleeding Index (MPBI), Probing Pocket Depth (PPD) and Clinical Attachment Level (CAL). Results: Both Placentrex® and Blue®M gels showed equal improvements in improving the clinical parameters at 4 weeks & 8-week intervals than SRP group alone. Conclusion: Incorporating Placentrex® and Blue®M as local drug delivery after SRP may serve as a beneficial adjunctive therapy in improving the clinical parameters in stage II periodontitis.