Towards Human-Precision Medicine Interaction

In this paper, we introduce the term Human-Precision Medicine Interaction (HPMI) to explore the convergence of Precision Medicine (PM) and HCI in advancing personalised healthcare. Building on our CHI 2025 paper titled Human-Precision Medicine Interaction: Public Perceptions of Polygenic Risk Score for Genetic Health Prediction, this work further examines the challenges and opportunities at the intersection of PM technologies and HCI. While PM technologies like Polygenic Risk Scores (PRS) have the potential to empower individuals, they also present significant challenges, including privacy concerns and anxiety induced by uncertainty. We argue that the successful realisation of PM's potential requires a careful integration of technological innovation with human values. This paper, thus, focuses on four key areas: identifying entry points for HCI contributions, addressing challenges in pilot implementations, managing stakeholder tensions, and understanding the roles of HCI in different PM technologies. We invite the CHI and wider HCI communities to engage in a dynamic dialogue on fostering a more human-centred approach to interactive PM and wider health.