Impact of digital health interventions on medication adherence and blood pressure control in Uzbek patients with resistant hypertension: a randomized controlled trial

The present study investigated the effect of digital health interventions on medication adherence and blood pressure management in resistant hypertension patients in Uzbekistan. The 190 patients took part in the randomized clinical trial, allocating them into two intervention and one control group. Besides routine care, the intervention group used a mobile app that had medication reminders, blood pressure measurement, and education, while the control group had only routine care. At 6-month follow-up, it was found that the digital intervention had a significant reduction in systolic blood pressure (24.3 mmHg compared to 9.1 mmHg in the control group, p<0.001). Medication adherence in the intervention group also improved to 94.8%, a 27.3% improvement from the baseline. In terms of blood pressure control, 74.6% of the patients in the intervention group achieved target blood pressure, and this was 35.2% for the control group (p<0.001). Results of nocturnal blood pressure monitoring also showed a decrease of 15.8 mmHg in the intervention group compared to a decrease of 6.3 mmHg in the control group. The study proves the effectiveness of digital health interventions as a practical and cost-effective method for the treatment of resistant hypertension in the Uzbek population.