Recent research advances in the application of Plant Derived Nanovesicles in the treatment of chronic diabetic wounds

Plant Derived Nanovesicles (PDNVs) have emerged as promising therapeutic agents for wound healing, particularly in the context of diabetic chronic wounds. These nanovesicles, secreted by plant cells, offer unique advantages such as high accessibility, low immunogenicity, and remarkable stability. Structurally composed of proteins, nucleic acids, and other bioactive molecules, PDNVs play pivotal roles in cell-to-cell communication and the modulation of various physiological processes. This review highlights their multifaceted functions, such as promoting cell proliferation and migration, the exertion of anti-inflammatory and antibacterial effects, and the stimulation of angiogenesis, all of which are critical for the complex process of wound repair. Furthermore, this review seeks to supply a thorough grasp of the current field status and to determine potential research pathways for the future. Special emphasis is placed on the latest advancements in utilizing PDNVs for the treatment of chronic diabetic wounds, unraveling their potential mechanisms and therapeutic impacts.