Maxillary Odontogenic Keratocyst with Secondary Infection: Diagnostic Dilemma and Surgical Management

Abstract Odontogenic Keratocyst (OKC) is a benign but locally aggressive cystic lesion of odontogenic origin, most commonly found in the mandible. Presentation in the maxilla, particularly with secondary infection, is less frequent and may mimic other cystic lesions. This case report describes a 25-year-old female presenting with a history of swelling in the right half of the palate following extraction of a grossly decayed maxillary first molar. Clinical and radiographic findings led to a provisional diagnosis of odontogenic keratocyst, which was confirmed by histopathology following surgical enucleation. The post-operative course was uneventful. This case underscores the importance of considering OKC in the differential diagnosis of persistent palatal swellings, particularly in the setting of recent dental extractions, and highlights the role of histopathology in the definitive diagnosis.