Precancerous Gallbladder Lesions in Cholelithiasis: A Histopathological Study

Chronic cholelithiasis was associated with significant mucosal changes, mainly epithelial hyperplasia, intestinal metaplasia, and low-grade dysplasia, supporting the metaplasia-dysplasia-carcinoma sequence. Alkaline phosphatase levels rose progressively with disease severity, indicating ongoing tissue injury. These findings highlight the importance of routine histopathological examination for early detection of precursor lesions.