Diagnostic value of dopamine transporter imaging with SPECT and PET in differentiating Parkinson's disease from atypical parkinsonian syndromes: A systematic review and meta-analysis

Parkinson's disease (PD) and atypical parkinsonian syndrome (APS) are both highly disabling neurodegenerative disorders. While they show significant overlap in clinical features, the therapies and prognoses are distinct. The differential diagnosis between PD and APS is challenging and critical for patient management. This study aimed to evaluate the diagnostic accuracy of dopamine transporter (DAT) radionuclide imaging in the differential diagnosis of PD and APS.