Insulin Resistance, Ca, C-reactive Protein and Some Hormonal Parameters Related with Vitamin D Deficiency in Hyperprolactinemic Women

Background & Objective: Hyperprolactinemia is a common endocrine disorder characterized by elevated serum prolactin levels, which can result in menstrual irregularities, galactorrhea, infertility, and hypogonadism in women.Beyond its well-known reproductive consequences, emerging evidence suggests that hyperprolactinemia may also be associated with significant metabolic and inflammatory alterations.This study aimed to investigate the relationship between vitamin D (Vit D) deficiency and hormonal (follicle-stimulating hormone [FSH], estradiol, thyroid-stimulating hormone [TSH], triiodothyronine [T3], thyroxine [T4]) and biochemical parameters (insulin resistance, calcium, and C-reactive protein [CRP]) in women with hyperprolactinemia. Materials & Methods:The study included 40 women aged 30-40 years, divided into two groups: 20 women with hyperprolactinemia and 20 healthy controls.Hormonal and biochemical parameters were measured in both groups, and comparisons were made to assess the effect of vitamin D deficiency.Results: FSH levels increased in the hyperprolactinemia group but were not statistically significant, while estradiol showed a significant increase (P 0.01).TSH and T4 levels were also significantly elevated (P 0.01), whereas T3 increased significantly (P 0.05) compared with the control group.Insulin resistance (P 0.05) and CRP (P 0.01) were significantly higher in the hyperprolactinemic group.Serum calcium levels decreased significantly (P 0.05) compared with the control group. Conclusion:Vitamin D deficiency in hyperprolactinemic women may be associated with various hormonal and metabolic disturbances.These include alteration of reproductive and thyroid hormone levels and elevation of inflammatory markers, suggesting that vitamin D deficiency may contribute to broader endocrine and biochemical dysregulation.