Radiation-induced sarcoma after glioma resection in patients with Li-Fraumeni syndrome: illustrative cases

These cases represent the first definitive report of cranial RIS following glioma chemoradiation therapy in patients with LFS. The short latency and aggressive nature of these tumors at the irradiated site highlight the need for proactive follow-up in patients with LFS after chemoradiation therapy to screen for RIS and improve outcomes through timely intervention. https://thejns.org/doi/10.3171/CASE25588.

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Publication Details

Journal
Journal of Neurosurgery Case Lessons
Published
2025-12-08
DOI
https://doi.org/10.3171/case25588
Citations
1
Primary Topic
Cancer-related Molecular Pathways
Type
article
Field-Weighted Citation Impact
1.05
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article

Radiation-induced sarcoma after glioma resection in patients with Li-Fraumeni syndrome: illustrative cases

1 citations
Journal of Neurosurgery Case Lessons
Cancer-related Molecular Pathways
1.05
article

Radiation-induced sarcoma after glioma resection in patients with Li-Fraumeni syndrome: illustrative cases

article en
1 citations

Abstract

These cases represent the first definitive report of cranial RIS following glioma chemoradiation therapy in patients with LFS. The short latency and aggressive nature of these tumors at the irradiated site highlight the need for proactive follow-up in patients with LFS after chemoradiation therapy to screen for RIS and improve outcomes through timely intervention. https://thejns.org/doi/10.3171/CASE25588.

Journal of Neurosurgery Case LessonsVol. 10(23)
University of California, San Francisco (US), Neurological Surgery (US)
Good health and well-being
Openalex Percentile: Top 15%
Cancer-related Molecular Pathways
1.05
DOIOpen Access PDFOpenAlex
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Radiation-induced sarcoma after glioma resection in patients with Li-Fraumeni syndrome: illustrative cases · Journal of Neurosurgery Case Lessons (2025) | TGRS Research Map | TGRS