UNVEILING THE MULTIPLE HORIZONS OF HYALURONIDASE IN AESTHETIC PRACTICE

Introduction: Hyaluronidase, an enzyme that has been used for decades in medicine, plays a crucial role in the dissolution of hyaluronic acid (HA) in aesthetic procedures. Objective: This study aims to explore the various applications of hyaluronidase, both approved and off-label, highlighting its relevance in aesthetic medicine. Methodology: The study consists of a literature review, analyzing scientific studies on the functions, efficacy, and potential side effects of this enzyme. Theoretical Framework: The discussion includes the natural presence of hyaluronidase in the body, its ability to break down HA, and the different sources of the enzyme, such as bovine, ovine, and recombinant. Additionally, the use of HA as a dermal filler, the associated risks like nodules and tissue necrosis, and the role of hyaluronidase in mitigating these complications are examined. The findings indicate that hyaluronidase is effective in reversing complications associated with HA use, emphasizing the importance of a detailed knowledge of facial anatomy and injection techniques to prevent severe issues, such as blindness and necrosis. Conclusion: It underscores that, despite the safety and efficacy of hyaluronidase, it is advisable to conduct skin sensitivity tests to prevent allergic reactions. The study reinforces the need for the appropriate use of hyaluronidase in aesthetic treatments and in preventing complications related to HA.