Organosilicone double-long-chain diquaternary ammonium salt acts as a biofilm scavenger to ameliorate colitis induced by dextran sulfate sodium salt

JUC Spray Dressing effectively removes intestinal bacterial biofilms, reduces inflammation, and enhances barrier function to alleviate UC symptoms. Its efficacy appeared comparable to conventional treatments, suggesting potential as an alternative therapeutic option; however, the present study did not assess mucosal safety, and dedicated toxicology studies are required to establish safety for intraluminal use.