LLM-Based Multi-Agent System and Simplicial Self-Supervised Learning Model for Regional Cancer Prevalence Estimation Using Satellite Imagery

Traditional cancer rate estimations are often limited in spatial resolutions and lack considerations of environmental factors. Satellite imagery has become a vital data source for monitoring diverse urban environments, supporting applications across environmental, socio-demographic, and public health domains. However, while deep learning (DL) tools, particularly convolutional neural networks, have demonstrated strong performance in extracting features from high-resolution imagery, their reliance on local spatial cues often limits their ability to capture complex, non-local, and higher-order structural information. To overcome this limitation, we propose a novel LLM-based multi-agent coordination system for satellite image analysis, which integrates visual and contextual reasoning through a simplicial contrastive learning framework (Agent-SNN). Our Agent-SNN contains two augmented superpixel-based graphs and maximizes mutual information between their latent simplicial complex representations, thereby enabling the system to learn both local and global topological features. The LLM-based agents generate structured prompts that guide the alignment of these representations across modalities. Experiments with satellite imagery of Los Angeles and San Diego demonstrate that Agent-SNN achieves significant improvements over state-of-the-art baselines in regional cancer prevalence estimation tasks.