Impact of the triglyceride–glucose–neutrophil-to-lymphocyte ratio and the C-reactive protein–TyG index on cardio-renal disease in patients with type 2 diabetes

In adults with type 2 diabetes, both CTI and TyG-NLR were independently associated with cardiorenal disease severity.Notably, TyG-NLR demonstrated a steeper risk gradient and modest improvements in discrimination and calibration, and it yielded slightly higher net clinical benefit across clinically relevant decision thresholds. These findings suggest potential clinical utility for risk stratification, although the overall predictive gain was moderate and requires further validation.