Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss
Together, these findings highlight a pioneering proof-of-concept platform that combines 3D MDSC spheroids, alginate-based delivery, and VEGF-mediated pharmacological preconditioning for VML repair. As a 100% unconditioned MDSC+alginate group was not included, the present study should not be interpreted as demonstrating <i>in vivo</i> superiority of VEGF preconditioning over unconditioned MDSCs; instead, it provides a rationale for future head-to-head studies explicitly powered to address this question.
Institutions
- University of Antwerp (BE)
- Universidade de São Paulo (BR)
- Universidade Presbiteriana Mackenzie (BR)
- Faculdade de Ciências Médicas da Santa Casa de São Paulo (BR)
- University of California, Davis (US)
- Universidade Federal de São Paulo (BR)
- University of Stavanger (NO)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.3389/fphar.2025.1657563
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Fonds Wetenschappelijk Onderzoek
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universiteit Antwerpen
- HORIZON EUROPE Framework Programme