KRT6A and KRT17 Mark Distinct Stem Cell Populations in the Adult Palpebral Conjunctiva and Meibomian Gland

<i>Krt6a</i>- and <i>Krt17</i>-expressing cells contribute to adult PC and MG homeostasis, respectively. KRT17 expression is enhanced by GLI2ΔN, and suppressed by HDAC3 and KLF4, whereas KRT6A expression is controlled only by HDAC3. These findings provide important biological insight into tissue-specific maintenance mechanisms and may inform future therapeutic strategies for regenerating MG and PC tissues affected by SC exhaustion or dysregulation.

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Publication Details

Journal
Cells
Published
2025-12-12
DOI
https://doi.org/10.3390/cells14241979
Primary Topic
Skin and Cellular Biology Research
Type
article
Field-Weighted Citation Impact
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article

KRT6A and KRT17 Mark Distinct Stem Cell Populations in the Adult Palpebral Conjunctiva and Meibomian Gland

Cells
Skin and Cellular Biology Research
article

KRT6A and KRT17 Mark Distinct Stem Cell Populations in the Adult Palpebral Conjunctiva and Meibomian Gland

article en

Abstract

<i>Krt6a</i>- and <i>Krt17</i>-expressing cells contribute to adult PC and MG homeostasis, respectively. KRT17 expression is enhanced by GLI2ΔN, and suppressed by HDAC3 and KLF4, whereas KRT6A expression is controlled only by HDAC3. These findings provide important biological insight into tissue-specific maintenance mechanisms and may inform future therapeutic strategies for regenerating MG and PC tissues affected by SC exhaustion or dysregulation.

CellsVol. 14(24)
Columbia University (US), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 36%
Skin and Cellular Biology Research
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